It’s safe for most people in early pregnancy—even with chronic health conditions.
However, it is not recommended if you have:

A known or suspected ectopic pregnancy

An IUD in place (must be removed before abortion)

Long-term steroid use (excluding inhalers)

Chronic adrenal failure

A bleeding disorder or are on blood thinners

Porphyria

Allergy to mifepristone or misoprostol
We also don’t recommend this method without imaging or labs if you’ve had:

A prior ectopic pregnancy

Tubal sterilization or surgery